New Study Shows Methotrexate Significantly Alleviates Pain and Stiffness for Millions with Knee Osteoarthritis in the UK

A recent study has given hope to millions suffering from knee osteoarthritis.

The research indicates that methotrexate, a drug commonly used for autoimmune conditions, may offer relief from the pain and stiffness associated with this debilitating disease.

This finding brings a sense of optimism to those struggling with the condition, potentially providing a new avenue for pain management.

In the UK alone, approximately 5.4 million people are affected by knee osteoarthritis, a condition where the joint deteriorates and fails to remain healthy and pain-free.

Current treatment options are often limited and offer only short-term relief. According to surveys by the charity Versus Arthritis, about one-third of people with osteoarthritis endure severe pain daily. This stark reality underscores the need for better treatment solutions.

Researchers from the University of Leeds and Leeds Teaching Hospitals NHS Trust conducted a study with 155 patients who were not finding relief from existing medications.

The participants were divided into two groups: one received a placebo, while the other was given methotrexate tablets weekly for 12 months.

The study, published in the *Annals of Internal Medicine*, revealed that those taking methotrexate reported less pain and stiffness after six months.

Methotrexate works by suppressing the immune system, which may explain its effectiveness.

Professor Philip Conaghan, a lead researcher, expressed excitement over these results, noting the significant potential for methotrexate to become a viable new treatment for osteoarthritis.

He highlighted that this drug could be particularly beneficial for patients with elevated blood inflammation levels.

Current Management and Future Prospects

Exercise, weight management, and physiotherapy are typically recommended for managing osteoarthritis. However, due to the severe pain and stiffness that many patients experience, additional treatments such as medication are often required.

Joint replacement surgery is another option for those with advanced osteoarthritis, but long NHS waiting lists can delay this much-needed relief.

Dr. Sarah Kingsbury, another researcher involved in the study, emphasized that while the results are promising, more research is needed before methotrexate can be widely recommended.

Future studies will aim to identify which patients benefit most from the drug, determine the optimal dosage, and evaluate the cost-effectiveness of methotrexate for treating osteoarthritis.

Impact on Patients and the Road Ahead

The impact of osteoarthritis can be profound, affecting a person’s ability to work, care for their family, and maintain independence.

Lucy Donaldson from Versus Arthritis, which funded the research, praised the study as a significant breakthrough.

She noted that despite progress in osteoarthritis research, there is still a long way to go, and new treatment options are urgently needed.

Veteran Roger Van-Cauter, 73, from Shropshire, shared his personal struggle with osteoarthritis, which has significantly impacted his quality of life. Despite being an avid athlete in his younger years, he now faces daily challenges due to the condition.

Van-Cauter’s story highlights the need for better treatments and the hope that research like this brings to those affected.

The recent findings offer a glimmer of hope for millions grappling with knee osteoarthritis, marking a step forward in the quest for effective pain relief and improved quality of life.

This article was published on TDPel Media. Thanks for reading!

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