Kick-off at the FNB Stadium is scheduled for 15:00.
Al Ahly will be out for revenge
Al Ahly, the defending champions, will be seeking revenge when they go up against the South African champions after losing their first group stage match to Masandawana 1-0 last weekend.
Mamelodi Sundowns currently lead the standings with seven points after three matches, while Al Ahly in second place on four points.
Only the top two sides in each of the four groups will progress to the quarter-finals.
Mosimane will be in a buoyant mood as he boards the flight to Mzansi having just put pen to paper on a new two-year contract at the Egyptian giants.