Cape Town All Stars could potentially finish as runners-up (but no better) with just one match remaining.
Those three clubs will play a round-robin ‘competition’ with the winner either claiming (or retaining) their place in the top-flight for the 2022/23 season.
The 16th and bottom side in the DStv Premiership will automatically be relegated.
LATEST GLADAFRICA CHAMPIONSHIP STANDINGS
All final day matches will kick off at 15:00.
Goal difference: +17
Goals scored: 39
The KwaZulu-Natal side are the heavy favourites to go up automatically as they host 14th-place Cape Town Spurs.
UNIVERSITY OF PRETORIA
Goal difference: +14
Goals scored: 40
Will host Hungry Lions in their final match and will expect a win against a team placed 12th in the league who have won only twice away this season.
CAPE TOWN ALL STARS
Goal difference: +12
Goals scored: 37
All Stars cannot win automatic promotion, but are assured of a place in the playoffs, with the only thing to be decided being whether they finish second or third.
They host fifth-placed JDR Stars in their final fixture.