“I really don’t know what to say,” an emotional Scheffler said afterwards.
“I’m just really pleased.
“It’s a tough week, a long week. I figured out my routine to keep some energy. But I’m pretty worn out right now to be honest.
“I’m pleased to be playing in it, and even more happy to win it.”
Victory could not have been sweeter for Scheffler, the fifth seed who defeated former world number one Dustin Johnson in the semi-finals earlier on Sunday and also eliminated defending champion Billy Horschel in the last 16 on Saturday.
Against the 29th seeded Kisner in Sunday’s final, Scheffler took control early on, going three up after six holes and playing flawlessly thereafter to retain his advantage.
Scheffler took the lead on the par-4 second hole when Kisner bogeyed after finding the greenside bunker with his second shot.
Scheffler then drained a 20-foot birdie putt on the par-3 fourth to go 2 up, and then two holes later extended his lead on the par-5 sixth with his third birdie of the round.
A superb third shot left him just just two feet from the cup for the simplest of birdie putts while Kisner could only make par.
Scottie Scheffler then extended his lead on the 14th with another birdie, rolling in a 15-foot putt to leave Kisner four down with four to play and staring at defeat.
Kisner needed something special on the 15th but the writing was on the wall after he could only land his second 20 feet from the hole.
Kisner missed the birdie putt to leave Scheffler two putts to seal the championship.
After rolling his first short, Kisner conceded to complete a memorable tournament for Scheffler, beaten in last year’s final by Horschel.
Kisner paid tribute to Scheffler in defeat.
“He’s playing incredible golf. I knew I needed my best – just couldn’t get my putter to cooperate,” Kisner said.
Scores from PGA Tour’s WGC-Dell Technologies Match Play at Austin Country Club, Texas on Sunday (USA unless stated; x denotes seed):
Scottie Scheffler (x5) bt Kevin Kisner (x29) 4&3
Corey Conners (CAN x36) bt Dustin Johnson (x8) 3&1
Scottie Scheffler (x5) bt Dustin Johnson (x8) 3&1
Kevin Kisner (x29) bt Corey Conners (CAN x36) 2-up
By Garrin Lambley © Agence France-Presse