Clarametyx Biosciences secures $33M in Series A funding

Investment Round Led by Ohio Innovation Fund

Clarametyx Biosciences has successfully secured a funding round led by Ohio Innovation Fund, with participation from existing investors such as Nationwide Children’s Hospital, Rev1 Ventures, JobsOhio Growth Capital, C Bio Investors, and 1776 Fund.

Accelerating Pipeline Efforts with Funding

The company plans to utilize the newly acquired funds to expedite its initiatives across the development pipeline.

Specifically, the focus will be on evaluating the potential of its lead therapeutic candidate, CMTX-101, in addressing infections in individuals with cystic fibrosis (CF).

Cystic fibrosis is a progressive, genetic disease impacting various organs, notably the lungs and pancreas.

Clarametyx’s Approach to Combatting Infections

Under the leadership of CEO David Richards, Clarametyx Biosciences is tackling the challenge of persistent and recalcitrant infections through a unique technology platform.

This platform targets the biofilm—a protective layer around bacteria—with the aim of facilitating a more effective immune response and antibiotic intervention.

The company is actively building a dynamic pipeline of immune-enabling therapies and vaccines, with a particular emphasis on life-threatening bacterial infections associated with biofilms.

Their near-term focus is on addressing challenging respiratory infections.

Clinical Trial Initiated for Lead Candidate CMTX-101

Concurrent with the fundraising efforts, Clarametyx has initiated a Phase 1b/2a clinical trial to assess the lead candidate, CMTX-101, in individuals with CF.

This comprehensive study will evaluate various aspects, including safety and tolerability, pharmacokinetics (PK), immunogenicity, reduction of pulmonary P. aeruginosa burden, and other exploratory endpoints.

CMTX-101 is being examined as an adjunct therapy alongside standard-of-care antibiotics for people with cystic fibrosis.

Conclusion and Future Prospects

As Clarametyx Biosciences advances in its clinical trial and pipeline development, the recent investment round marks a significant step forward. With a strategic focus on addressing biofilm-associated infections, particularly in the realm of respiratory health, the company aims to contribute innovative solutions to combat life-threatening bacterial infections. The ongoing evaluation of CMTX-101 in the clinical trial underscores Clarametyx’s commitment to advancing therapeutic options for individuals with cystic fibrosis.

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