Kick-off at the Nelson Mandela Bay Stadium is at 17:00.
Hlanti has been out for months now, and while he was expected to be back earlier this year, Baxter said the Bafana Bafana international had a setback.
Furthermore, Baxter confirmed that Lebogang Manyama is also not available after going down on his knees with a troubled cartilage.
Leonardo Castro is back in full training but Baxter said the striker will not be considered for selection against Chippa United probably because of his fitness.
The good news, though, is that midfielder Cole Alexander is back in full training and available for selection for the clash against Chippa United.
KAIZER CHIEFS TO MISS FOUR KEY PLAYERS FOR CHIPPA UNITED CLASH
“We’ve lost Tower (Erick Mathoho) this week. He twisted his ankle blocking a shot,” Baxter told the Chiefs website.
“Lebogang Manyama broke down with his knees, it’s cartilage trouble and that’s going to keep him out for a while.
“Cole Alexander has come back; he’s been training for about 10 days. He played in an internal practice game and came through it okay, so he’s available.
“Leonardo Castro is not available but is back in full training.
“S’fiso Hlanti had a bit of a setback, but that’s the way it is with Achilles. The scar tissue causes some problems and it feels like he’s damaged it, but he hasn’t, it’s just scar tissue.