FBI Prepares to Compare DNA From Glove With National Database as Investigators Hunt Suspect in Nancy Guthrie Disappearance in Tucson

Investigators may finally be closing in on a breakthrough in the high-profile disappearance of Nancy Guthrie, the 84-year-old mother of Today show co-host Savannah Guthrie.

A discarded glove, found just a few miles from her Tucson home, is now set to have its DNA tested against the FBI’s national database, potentially identifying the masked figure seen outside her residence the night she vanished.

The case, which has gripped the nation for weeks, has been marked by tense uncertainty, and this piece of evidence could offer the critical lead authorities have long awaited.

The Glove That Could Provide Answers

The glove in question was discovered about two miles from Guthrie’s home in Tucson’s upscale Catalina Foothills neighborhood.

Authorities immediately treated it as a key piece of evidence, believing it might be connected to the suspect captured on surveillance footage near her front door.

Early DNA analysis suggests the genetic material could belong to the same person seen on video — a masked man wearing gloves, a jacket, long pants, and carrying a distinctive backpack.

Officials are awaiting confirmation before expanding their forensic comparisons against federal criminal databases.

The Circumstances of Nancy Guthrie’s Disappearance

Nancy Guthrie was last seen on January 31 at her home, and reported missing the next day.

Authorities have expressed concern for her wellbeing, noting her need for daily medications, her pacemaker, and a history of high blood pressure and heart problems.

Blood discovered on her front porch raises fears that she may have been harmed during the encounter.

Surveillance footage shows a man approximately 5 feet 9 inches tall, of medium build, wearing a mask and gloves, carrying a 25-liter Ozark Trail Hiker Pack purchased at Walmart — a detail investigators hope could help pinpoint his identity.

Investigators Follow Every Lead

Authorities have worked quickly to explore all angles.

Pima County Sheriff Chris Nanos confirmed that law enforcement is collaborating with Walmart to check purchase records and surveillance footage.

Clothing linked to the suspect may also have originated there, though the items are widely sold.

Multiple gloves have been found near the home, most belonging to searchers and volunteers, but the glove undergoing DNA testing appears unique and potentially tied to the suspect.

Forensic teams have combed the area, sealing off roads and coordinating closely with FBI agents.

Massive Public Response and Nationwide Attention

The case has captured national attention.

The FBI has received more than 13,000 tips, and the Pima County Sheriff’s Department reported taking around 18,000 calls, generating between 40,000 and 50,000 investigative leads.

Despite this overwhelming volume, investigators emphasize the importance of filtering actionable information from false alarms.

Sheriff Nanos has publicly cleared Guthrie’s family as suspects, highlighting the emotional toll the investigation has taken on them.

“The Guthrie family are victims, plain and simple,” Nanos said.

“To suggest otherwise is not only wrong, it is cruel.”

Broader Investigative Efforts

Authorities have conducted court-authorized searches, detained individuals for questioning, and seized vehicles believed to be linked to the case.

Federal agents have also canvassed gun stores as part of standard investigative procedures.

Officials caution that while some details are made public to enlist help, excessive reporting could compromise the investigation, giving the perpetrator insight into law enforcement’s actions.

Savannah Guthrie’s Emotional Plea

Amid the national spotlight, Savannah Guthrie has made heartfelt appeals for her mother’s safe return.

In a recent Instagram video, she addressed anyone who may be holding her mother: “It is never too late to do the right thing. And we are here.

And we believe in the essential goodness of every human being, that it’s never too late.”

National Leaders Weigh In

Even President Donald Trump commented on the case, expressing optimism for a positive outcome and warning that anyone responsible could face the harshest penalties.

He suggested that, should Nancy Guthrie be found deceased, the punishment could include the death penalty.

What’s Next?

Investigators are preparing to enter the glove’s DNA into the FBI’s CODIS system, which could provide the critical match needed to identify the suspect.

As the search continues, authorities will continue following leads, analyzing tips, and exploring every investigative avenue.

Meanwhile, the public is urged to remain vigilant and report any information without interfering with official operations.

The next few days could be pivotal in uncovering what happened to Nancy Guthrie.

Summary

Nancy Guthrie’s disappearance has gripped the nation for weeks, but a discarded glove found near her Tucson home may finally offer a key lead.

DNA from the glove is being compared against national databases in hopes of identifying the masked suspect captured on surveillance video.

Investigators are following a wide array of leads, collaborating with retailers, canvassing neighborhoods, and analyzing tens of thousands of tips.

The Guthrie family has been cleared as suspects, and public appeals, including those from Savannah Guthrie, continue to call for the safe return of Nancy.

With the DNA testing underway, authorities are cautiously optimistic that progress could be made soon.