Rosie O’Donnell is still wrapping her head around a major transformation.
The 63-year-old former talk show host has been on a health journey since late 2022, and with the help of the diabetes medication Mounjaro, she’s achieved a slimmed-down figure she never imagined possible.
In her latest Instagram post, Rosie revealed that she now wears a size 12—something she says still feels surreal—and called the drug a true “life saver.”
A Shopping Trip Turns Into a Milestone
Rosie shared her disbelief after going shopping for comfortable loungewear for an upcoming 22-hour flight to Australia.
Wearing a fitted black tracksuit in the dressing room, she admitted she still struggles to see herself in this “new smaller body.”
“Cam and Robin took this photo of me… I am shocked I’m a 12,” she wrote. “#mounjaro is a life saver.”
Fans flooded the comments with praise. Kristin Chenoweth told her, “You look amazing!” while another follower shared how the medication not only helps with weight loss but also reduces inflammation.
One fan added, “Your beautiful soul shines through in ANY body.”
How Mounjaro Changed Her Health
According to the official site, Mounjaro is an injectable prescription drug designed to help adults with type 2 diabetes manage blood sugar, used alongside diet and exercise.
For Rosie, it has also been a game-changer for weight loss, energy, and overall health.
Back in March, she spoke on TikTok about her “shocking” size drop.
She explained that while Mounjaro played a big role, her lifestyle also changed—she no longer had a personal chef and now cooks meals for herself and her child, Clay.
From XL to Large in Dublin
Rosie recalled a trip to a clothing store in Dublin where she discovered she had gone from wearing XL or XXL to a size large.
“I find it completely shocking,” she admitted, adding that she feels healthier, sleeps better, and has more energy since starting the medication.
Early Days on the Medication
Rosie first revealed in January 2023 that she had been prescribed Mounjaro.
By the end of the holiday season, she had already lost 10 pounds.
On TikTok, she credited her progress to a mix of the medication, cutting out most sugary drinks—especially the five or six Diet Cokes she used to have daily—and sticking mostly to water.
She did allow herself the occasional glass of champagne or wine, but overall, her appetite decreased significantly, and she began moving more.
A New Perspective on Herself
Even now, Rosie says she’s still getting used to the reflection she sees.
In a recent stand-up performance photo she posted, she captioned it: “I can’t believe this is me now #mounjaro #weightloss #bodydysmorphia.”
Her journey has not only been about numbers on a scale but also about adjusting to a healthier, more confident, and energetic life.