Experts warn Ozempic users in New York and beyond may experience sagging skin and facial aging as rapid weight loss leads to volume loss around the mouth

So you’ve trimmed down with the help of Ozempic—but now you’re noticing something a little off in the mirror.

Maybe your face looks a bit more tired, your smile lines are deeper, or your lips aren’t as full as they used to be.

You’re not imagining it.

There’s a growing concern among cosmetic experts about a new phenomenon called “Ozempic mouth”—and it’s becoming a hot topic in both Hollywood and dermatology clinics.

What Is “Ozempic Mouth” and Why Is It Happening?

Dr. Michele Green, a New York-based cosmetic dermatologist, says she’s seeing more and more patients with noticeable volume loss around their mouths after starting Ozempic.

This isn’t just about looking a bit older—some users are seeing deep lines, sagging skin, and even jowls forming around the chin and lips.

It’s all part of a bigger issue known as “Ozempic face,” where rapid weight loss leads to hollow cheeks and a gaunter appearance overall.

Celebrities Are Seeing It Too

This isn’t just a concern for everyday users.

Dr. Green pointed out that celebs like Sharon Osbourne, Rebel Wilson, and Whoopi Goldberg have shown signs of Ozempic’s effects on the face. A

ctor Harvey Fierstein, who’s openly taken another weight-loss drug called Zepbound, reportedly lost 120 pounds and now shows sagging in the jawline and face.

The changes are subtle but visible—and they’ve sparked a new wave of cosmetic concern.

Why It Happens: The Science Behind the Sag

The main issue is that Ozempic depletes subcutaneous fat—the soft layer just under your skin that gives your face a plump, youthful appearance.

As this layer shrinks, the skin has less support, which means more wrinkles, thin-looking skin, and those dreaded “lipstick lines” that make the mouth look older.

Plastic surgeon Dr. Barry Weintraub explains that this fat loss can also interfere with water retention in the skin, making dryness and sagging even worse.

Fillers to the Rescue—But at a Price

The good news?

There are ways to fight back against Ozempic mouth.

Fillers—gel-like substances injected beneath the skin—can help restore volume, smooth out fine lines, and give the face a fresher, more youthful contour.

But they don’t come cheap.

Each syringe can cost anywhere from $700 to $2,000 depending on where you go.

And as demand for Ozempic has exploded, so too has the demand for fillers.

In the U.S., the number of filler procedures has nearly tripled in the past decade, from 1.8 million in 2010 to over 5 million in 2023.

Another Option: Thermage Skin Tightening

If needles aren’t your thing, another solution Dr. Green recommends is Thermage.

This is a non-invasive radiofrequency treatment that tightens skin and boosts collagen production—your body’s natural filler. Results take a few months to show but can last over a year.

Still, it’s not a cheap fix. A single 30-minute session can cost between $1,500 and $3,500.

The Best Approach? Prevention Over Cure

While cosmetic fixes can help, Dr. Green stresses the importance of managing the root issue—rapid weight loss.

She advises Ozempic users to talk with their doctors about adjusting dosage for a slower, more gradual slim down.

This can help minimize the shock to the skin and reduce the likelihood of volume loss in the first place.

Don’t Forget the Basics: Hydration and Nutrition

Dr. Ilana Ramer Bass from Mount Sinai Health System also has some back-to-basics advice. She encourages Ozempic users to eat small, balanced meals rich in fiber and protein to keep the skin hydrated and healthy.

And before turning to cosmetic treatments, she recommends seeing a dermatologist if you notice changes in your skin.

Not Just the Mouth—Ozempic’s Impact Spreads

“Ozempic mouth” isn’t the only side effect making headlines.

There’s also “Ozempic face,” “Ozempic feet,” and even “Ozempic butt.”

That last one refers to a deflated backside some users report after major weight loss—some say they can now feel every bone and are constantly covering up.

Celebs like Katy Perry, Jessica Simpson, and Scott Disick have all faced speculation about Ozempic-related changes, especially with sunken cheeks or overly slimmed-down looks in recent public appearances.

Final Thoughts: Know What You’re Signing Up For

While Ozempic and similar medications like Mounjaro and Wegovy offer powerful tools for weight loss, they can come with some unexpected—and very visible—trade-offs.

If you’re considering or currently using one of these medications, keep your skin health and facial appearance in mind.

Prevention, smart skincare, and expert advice can go a long way in helping you stay healthy—and confident—in your new body.